Investigate the role of Alpha -1- antitrypsin (A1AT) and Alpha-Fetoprotein (AFP) in hepatocellular carcinoma among Iraqi patients.. Alpha-1-antitrypsin deficiency,
Conditions
Interventions
Control group: The control group, contains 100 healthy volunteers with unrelated healthy blood donors, free of any chronic diseases, living in the same geographical area recruited as normal healthy co
they were 78 males and 22 females with a mean age of 55.12 ± 11.36 years..
Sponsors
University of Sousse
The university of sousse
Eligibility
Sex/Gender
All
Age
50 Years to 60 Years
Inclusion criteria
Inclusion criteria: This case-control study was conducted on 100 HCC patients being treated at the National Liver Institute Hospital, Baghdad University, Iraq. All of the participants were Iraqis. As control subjects, 100 age- and sex-matched healthy blood donors with no history of malignant or genetic diseases provided blood samples. Until analysis, blood and plasma samples were kept at 80 °C.
Exclusion criteria
Exclusion criteria: Individuals with a documented medical history of malignancy and genetic disorders were not included in the study. Individuals with a higher incidence of the disease in regions other than the liver were excluded from the study. Exclusions were made for patients who expired within the duration of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alpha -1- antitrypsin. Timepoint: Before intervention and 10 weeks after intervention. Method of measurement: The plasma A1AT level was measured by nephelometry using commercially available antibodies (MININEPH, Birmingham, UK), with an Array™ Protein System autoanalyzer (Beckman Instruments, Brea, California, USA). | — |
Countries
Iraq
Contacts
Public ContactBassem Charfeddine
University of Sousse
Outcome results
None listed