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The effect of combined exercise on plasma levels of alpha-glucose, sirtuin 1, oxidative enzymes, lipid profile and glucose homeostasis in obese men aged 60 to 70 years.

The effect of combined exercise on plasma levels of alpha-klotho, sirtuin 1, oxidative enzymes, lipid profile and glucose homeostasis in obese men aged 60 to 70 years.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230810059112N1
Enrollment
46
Registered
2023-09-18
Start date
2022-04-14
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study subjects are obese. Overweight and obesity

Interventions

Intervention 1: IntervIn this study, the intervention is sports training, which will be combined training (resistance, endurance) for 16 weeks and 3 sessions per week for 60 minutes. Before the start

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
60 Years to 70 Years

Inclusion criteria

Inclusion criteria: The subjects were between 60 and 70 years old People who have the ability to implement the training protocol and tests Stable body weight (±5 kg) for at least six months Ability to perform the exercise intervention (exercise capacity) and participants consuming an omnivorous diet

Exclusion criteria

Exclusion criteria: History of orthopedic diseases in the last 5 years and vision problems Having daily sports activities for at least two years Having suspicious cases such as cardiovascular disease, angina pectoris, myocardial infarction, stroke, peripheral artery occlusion disease Having kidney failure and liver disease, coagulation disorders, chronic gastrointestinal disorders (e.g. Crohn's disease), pancreatic insufficiency, immunological disease (e.g. autoimmune disease) and not taking immunosuppressive drugs or laxatives, heart failure, cardiac arrhythmia, type 1 and 2 diabetes

Design outcomes

Primary

MeasureTime frame
Levels of klotho. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Sirtuin1. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Catalase enzyme. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Superoxide dismutase enzyme. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Total antioxidant capacity. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;FOXO1. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Insulin-like growth factor-1 (IGF-1). Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Insulin. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: ELISA method.;Fasting blood sugar. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: By photometric enzymic calorimetric.;Triglyceride. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: Enzymatic calorimetric method.;High density lipoprotein. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: Enzymatic calorimetric method.;Low density lipoprotein. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: Through the equation of Friedwald et al(LDL = TC - HDL - TG/0.5.;Total cholesterol. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: Enzymatic photometric method.;Ability and capacity to perform basic movements and mobility. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: TUG standing and walking time test.;Aerobic strength. Timepoint: Before and after the end of 16 weeks of training. Method of measurement: Using Racport.;Hand and paw strength test(hand grip). Tim

Secondary

MeasureTime frame
Blood pressure and heart rate. Timepoint: Before and after 16 weeks of training. Method of measurement: Variables were measured at rest and after exercise with a sphygmomanometer, systolic and diastolic blood pressure and heart rate.;Body composition. Timepoint: Before and after 16 weeks of training. Method of measurement: Using weight, body mass index, waist to hip ratio and fat percentage.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Safari Sharafshadeh

Islamic Azad University

ma6692.safari@gmail.com+98 13 3342 4080

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026