Effect of Pregabalin on postoperative pain after anterior cruciate ligament (ACL) reconstruction

The efficacy of Pregabalin compared to placebo in management of acute postoperative pain after anterior cruciate ligament (ACL) reconstruction surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230809059098N1

Enrollment

132

Registered

2023-11-29

Start date

2023-10-23

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain. Pain in joint

Interventions

Intervention 1: Intervention group: A single dose of pregabalin from Tehran Shimi Company, 150 mg, is taken 2 hours before surgery with a glass of water. Intervention 2: Control group: A single dose p

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 45 who undergo arthroscopy for anterior cruciate ligament reconstruction in Akhtar Hospital in 1402 are included in the study.

Exclusion criteria

Exclusion criteria: Any known allergies or contraindications to pregabalin History of heart, kidney or liver disease Preoperative use of antidepressants or anticonvulsants History of drug or alcohol addiction Nonsteroidal anti-inflammatory drugs (NSAIDs) or opioids use 48 hours before surgery Patients who underwent meniscus reconstruction or allografts were used

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: 6, 12, 24 hours postoperatively. Method of measurement: Numeric pain scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEmad Kouhestani

Shahid Beheshti University of Medical Sciences

emadkouhestani@gmail.com+98 21 2260 1761

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026