Enhancing lymph node detection in rectal specimens: The role of Methylene Blue arterial injection

Comparison of the amount of identified lymph nodes involved in the resected sample of rectal cancer before and after injection of methylene blue in the main artery of the sample

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230809059096N2

Enrollment

Registered

2024-02-17

Start date

2018-12-22

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant neoplasm of rectum. Malignant neoplasm of rectum

Interventions

Intervention 1: Intervention group: The inferior mesenteric arteries of 33 specimens were cannulated with a standard 17–20-G iv-catheter by the surgeon who is using this technique in order to check th

ratio 1:1).and then specimen refer to pathology laboratory. Intervention 2: Control group: Total mesorectal dissection performed for control group with out any arterial injection.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 80 Rectum cancer

Exclusion criteria

Exclusion criteria: Massive and invasive tumors that require a special technique for resection Neoadjuvant therapy Metastasis Inflammatory bowel disease

Design outcomes

Primary

Measure	Time frame
Determining the average number of identified lymph nodes involved in the resected sample of rectal cancer by injecting methylene blue in the main artery of the sample. Timepoint: 15 days. Method of measurement: pathology.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Alvandipour

Mazandaran University of Medical Sciences

Minaalvh@yahoo.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026