Idiopathic oligoasthenoteratospermia. Male infertility, unspecified
Conditions
Interventions
Intervention 1: Intervention group: The group of patients receiving 100 mg capsule of CoQ10 BD and 500 mg capsule of probiotic FamiLact daily for a period of 70 days (after food consumption). The prob
Sponsors
Kashan University of Medical Sciences
Vice Chancellor of Research & Technology
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Definitive diagnosis of idiopathic oligoasthenospermia
Exclusion criteria
Exclusion criteria: People who take drugs affecting spermatogenesis such as tamoxifen, HCG, gonadotropin, androgens and cytotoxic drugs such as immunosuppressants, anticonvulsants, and antibiotic or antifungal drugs. People who have a diet rich in probiotics. People who have factors with a clear effect on the condition of asthenozoospermia include: varicocele, epididymovarcitis, prostatitis, history of testicular surgery, testicular trauma, testicular torsion, history of intracytoplasmic sperm injection (ICSI), history of chemotherapy, radiotherapy, abnormality. chromosomal abnormalities, cryptorchidism, hypogonadism, recent history of sexually transmitted diseases, pyospermia, smoking, alcohol, drugs, known hormonal disorders, diabetes, known liver and kidney disease, BMI over 30 Unwillingness to cooperate and participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression. Timepoint: Before the intervention and after the intervention. Method of measurement: Real-time PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sperm concentration. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Semen volume. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of abnormal sperm morphology. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of sperm motility. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Percentage of sperm progressive motility. Timepoint: Before the intervention and after the intervention. Method of measurement: Semen sample analysis.;Total antioxidant capacity (TAC). Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA.;Malondialdehyde (MDA) level. Timepoint: Before the intervention and after the intervention. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Elahesadat Seyyedhoseini
Kashan University of Medical Sciences
Outcome results
None listed