Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention group: The tests before the injection are performed on an outpatient basis and the patient is admitted to the hospital on the day of the injection, and the patient will be hospitalized fo
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: MS diagnosed based on McDonalds criteria Secondary progressive patients who are treated with monoclonal antibodies EDSS score between 2 and 7 after at least 3 months have passed since the last attack
Exclusion criteria
Exclusion criteria: Active proliferative retinopathy Poor diabetes control (HbA1c greater than 8.5) Renal failure (creatinine more than 2.5) Infection (WBC more than 15000 and/or body temperature more than 38 degrees Celsius) Organ transplant history Active malignancy or its history in the past Cardiovascular disease pregnant women Having a positive PCR test for Covid-19 Mental disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The danger and side effects of mesenchymal stem cell transplantation in terms of causing pain. Timepoint: injection day and 1, 3, 6 and 12 months after stem cell injection. Method of measurement: Patient self-report.;Degree of disability. Timepoint: before injection and 1, 3 and 12 months after stem cell injection. Method of measurement: with EDSS index.;Safety and side effects of mesenchymal stem cell transplantation in terms of hypersensitivity. Timepoint: injection day and 1, 3, 6 and 12 months after stem cell injection. Method of measurement: Clinical observation.;The safety of stem cell injection in terms of causing infection and inflammation. Timepoint: injection day and 1, 3, 6 and 12 months after stem cell injection. Method of measurement: CBC ESR CRP.;The safety of stem cell injection in terms of damage to the liver. Timepoint: injection day and 1, 3, 6 and 12 months after stem cell injection. Method of measurement: AST ALT.;The safety of stem cell injection in terms of kidney dysfunction. Timepoint: injection day and 1, 3, 6 and 12 months after stem cell injection. Method of measurement: BUN Creatinine U/A. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Javad Hosseini Nejad Anbaran
Bagheiat-allah University of Medical Sciences
Outcome results
None listed