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Investigating the effect of inhaled verapamil on pulmonary artery systolic pressure in patients with chronic obstructive pulmonary disease

Investigating the effect of inhaled verapamil on pulmonary artery systolic pressure in patients with chronic obstructive pulmonary disease hospitalized in Imam Khomeini Hospital, Tehran: a randomized, double-blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230804059027N1
Enrollment
46
Registered
2023-08-12
Start date
2023-08-07
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obsrtuctive pulmonary disease. Other secondary pulmonary hypertension

Interventions

Intervention 1: Intervention In the intervention group: with chronic obstructive pulmonary disease hospitalized in Imam Khomeini Hospital in this group, verapamil in the form of inhalation and in the

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with proven chronic obstructive pulmonary disease based on spirometry criteria and patient history Patients with proven chronic obstructive pulmonary disease and hospitalized in Imam Khomeini Hospital

Exclusion criteria

Exclusion criteria: Valvular heart disease more than moderate Pulmonary valve stenosis History of renal failure History of liver cirrhosis History of pulmonary embolism Congenital heart disease

Design outcomes

Primary

MeasureTime frame
Pulmonary artery systolic pressure reduction. Timepoint: Pulmonary artery systolic pressure was measured by echocardiography at the beginning of the study (before the intervention) and 1 hour after receiving inhaled verapamil. Method of measurement: Echocardiography device Affiniti 50.

Secondary

MeasureTime frame
The increase in oxygen saturation of arterial blood. Timepoint: Arterial blood oxygen saturation is measured before receiving inhaled verapamil (pre-intervention) and 1 hour after the intervention. Method of measurement: Measurement of arterial blood oxygen saturation is done by finger pulse oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Kazem Gharloghi

Tehran University of Medical Sciences

Dr.K.Gharloghi@gmail.com+98 21 6119 2762

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026