Studying effect of Dexmedetomidine on postoprative Nausea & Vomiting(PONV)

Studying effect of Dexmedetomidine on postoprative Nausea & Vomiting(PONV)In Laparascopic Cholecystectomy in Addict patient

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230728058951N1

Enrollment

100

Registered

2023-10-22

Start date

2023-11-22

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of dexmedetomidine on postoperative nausea and vomiting (PONV). Nausea and vomiting

Interventions

Intervention 1: intervention group: The intervention group (including 50 people) will be subjected to intravenous infusion of dexmethomidine (an alpha 2 agonist drug) with dose of 1 mcg/kg/min, just f

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with a history of addiction (according to definition) Age between 20 and 60 years ASA class one and two Blood pressure 24 hours before and during the operation between 140 and 90 mmHg

Exclusion criteria

Exclusion criteria: Intraoperative laparotomy Surgery lasting more than 4 hours Heavy bleeding ASA class three Any history of heart disease History of gastrointestinal disease Presence of nausea and vomiting before surgery Drug withdrawal symptoms before surgery Taking antiemetics History of motion sickness or PONV

Design outcomes

Primary

Measure	Time frame
Post operative Nausea and vomiting (ponv) is one of the most unpleasant experiences that has important consequences on patient satisfaction, treatment results and related costs, and is one of the common causes of morbidity after surgery. Grades of (ponv) include nausea, retching, regurgitation or vomiting. ? ponv:It is one of the common causes of morbidity after surgery, which usually occurs during the recovery phase and ends spontaneously within 24 hours.it includes nausea that can end in retching or vomiting or regurgitation. ? Nausea:This is an unpleasant feeling that refers to the urge to vomit and is not accompanied by muscle movement outside the driver. ? Vomiting:It is the strong excretion of even small amounts of the contents of the upper GI tract through the mouth. ? Regurgitation:It is the exit of material from the pharynx or esophagus with low pressure, which is usually characterized by the presence of undigested food or blood. ? Retching:When even with muscular ejector efforts, no contents of the stomach are expelled through the mouth. Timepoint: Measurement of presence Post operative nausea & vomitting and its levels in 15, 30, 45, 60, 90 and 120 minutes after the operation. Method of measurement: The interview includes asking the patient or the patient's complaint (in cases of nausea and regurgitation) and observation (in cases of vomiting and retching).	—

Measure

Time frame

Post operative Nausea and vomiting (ponv) is one of the most unpleasant experiences that has important consequences on patient satisfaction, treatment results and related costs, and is one of the common causes of morbidity after surgery. Grades of (ponv) include nausea, retching, regurgitation or vomiting. ? ponv:It is one of the common causes of morbidity after surgery, which usually occurs during the recovery phase and ends spontaneously within 24 hours.it includes nausea that can end in retching or vomiting or regurgitation. ? Nausea:This is an unpleasant feeling that refers to the urge to vomit and is not accompanied by muscle movement outside the driver. ? Vomiting:It is the strong excretion of even small amounts of the contents of the upper GI tract through the mouth. ? Regurgitation:It is the exit of material from the pharynx or esophagus with low pressure, which is usually characterized by the presence of undigested food or blood. ? Retching:When even with muscular ejector efforts, no contents of the stomach are expelled through the mouth. Timepoint: Measurement of presence Post operative nausea & vomitting and its levels in 15, 30, 45, 60, 90 and 120 minutes after the operation. Method of measurement: The interview includes asking the patient or the patient's complaint (in cases of nausea and regurgitation) and observation (in cases of vomiting and retching).

—

Secondary

Measure	Time frame
The secondary outcome variables are the degrees of postoperative nausea and vomiting including: nausea, regurgitation, retching, and vomiting, which were explained earlier. Timepoint: Measuring the degree of postoperative nausea and vomiting in 15, 30, 45, 60, 90 and 120 minutes after the surgery. Method of measurement: The interview includes asking the patient or the patient's complaint (in cases of nausea and regurgitation) and observation (in cases of vomiting and retching).	—

Measure

Time frame

The secondary outcome variables are the degrees of postoperative nausea and vomiting including: nausea, regurgitation, retching, and vomiting, which were explained earlier. Timepoint: Measuring the degree of postoperative nausea and vomiting in 15, 30, 45, 60, 90 and 120 minutes after the surgery. Method of measurement: The interview includes asking the patient or the patient's complaint (in cases of nausea and regurgitation) and observation (in cases of vomiting and retching).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamad Hosein Rezaei

Shahid Beheshti University of Medical Sciences

sepidsaman35@gmail.com+98 21 2640 9546

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026