Comparison of side effects caused by injection of Hyaluronic acid dermal fillers of two brands, Restylane and Perfectha, in the under eye area

Comparison of side effects (sensitivity and redness, tissue necrosis, accumulation of mass under the skin) caused by injection of Hyaluronic Acid dermal fillers of two brands, Restylane and Perfectha, under the eye area of ??patients referred for skin rejuvenation.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230724058912N1

Enrollment

Registered

2023-09-02

Start date

2023-09-06

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications caused by injecting hyaluronic acid dermal fillers in the under eye area. Adverse effect of other drugs, medicaments and biological substances

Interventions

Intervention 1: The first intervention group: the group of 43 people receiving Restylane filler, Restylane filler, which is made of non-animal hyaluronic acid and is produced by a Swedish company in p

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Hyaluronic acid injection in the under eye area age between 18 to 70 informed consent

Exclusion criteria

Exclusion criteria: History of bleeding diseases History of eye surgery in the last month

Design outcomes

Primary

Measure	Time frame
Inflammation and redness of the area based on the dermatologist examination. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.;Mass accumulation under the skin. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.;Skin necrosis. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.	—

Measure

Time frame

Inflammation and redness of the area based on the dermatologist examination. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.;Mass accumulation under the skin. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.;Skin necrosis. Timepoint: 7 days, one month and two months after hyaluronic acid injection. Method of measurement: The opinion of two dermatologist separately.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEnsie Keshvari

Islamic Azad University

keshvari75@yahoo.com+98 21 3371 4516

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026