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The effect of dehydroepiandrosterone vaginal tablets in ripening cervical preparation for labor and the process of labor

A comparative study of the effect of dehydroepiandrosterone (DHEA) plus misoprostol with misoprostol alone in accelerating of cervical ripening for delivery and its process in nulliparous women in Akbarabadi Hospital from 2023 to 2025

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230722058884N2
Enrollment
130
Registered
2025-01-03
Start date
2024-12-21
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Natural Virginal Delivery. Spontaneous vertex delivery

Interventions

Intervention 1: Intervention group: In this group, patients receive both oral misoprostol and a 25 mg vaginal dehydroepiandrosterone tablet. This group is considered the intervention group. Interventi

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Primipara Single pregnancy Late term and preterm pregnancy (gestational age more than 34 weeks) Bishop scores less than 4 at the time of admission

Exclusion criteria

Exclusion criteria: Macrosomia Cephalic Pelvic disproportion History of myomectomy and entry into the endometrial cavity Repeat cesarean History of spinal injury that precludes natural vaginal delivery Patient with heart or brain issues precludes natural vaginal delivery

Design outcomes

Primary

MeasureTime frame
Evaluation of Cervical Bishop Score in Labor Progression Using Vaginal Examination. Timepoint: Every one to two hours. Method of measurement: Vaginal examination.

Secondary

MeasureTime frame
Measurement of Cervical Dilation Progression in the First Stage of Labor and Evaluation of Fetal Descent Speed and Duration in the Second Stage. Timepoint: Every 1 to 2 hours from admitting to labor up to delivery. Method of measurement: Vaginal examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Ghaderi

Iran University of Medical Sciences

elahe_ghaderi@outlook.com+98 21 5560 6034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026