The effect of different levels of positive end-expiratory pressure on respiratory function in laparoscopic cholecystectomy candidates

Comparison of different levels of positive end-expiratory pressure on the respiratory function in laparoscopic cholecystectomy candidates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230719058854N1

Enrollment

Registered

2023-07-24

Start date

2023-08-06

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory support during elective laparoscopic cholecystectomy.

Interventions

Intervention 1: Intervention group: Positive end-expiratory pressure of 5 cm H2O. Intervention 2: Intervention group: Positive end-expiratory pressure of 7 cm H2O. Intervention 3: Control group: Posit

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18-70 years ASA class I and II

Exclusion criteria

Exclusion criteria: Hemodynamic instability Severe heart failure Renal failure Respiratory failure Pulmonary embolism Air embolism during the operation Complications of laparoscopy leading to laparotomy History of chronic respiratory diseases, asthma, and chronic obstructive pulmonary disease

Design outcomes

Primary

Measure	Time frame
Partial pressure of arterial oxygen. Timepoint: 30 min after intubation. Method of measurement: Arterial blood gas (ABG).	—

Secondary

Measure	Time frame
Partial pressure of carbon dioxide in arterial blood. Timepoint: 30 min after intubation. Method of measurement: Arterial blood gas (ABG).;PH. Timepoint: 30 min after intubation. Method of measurement: Arterial blood gas (ABG).;End-tidal carbon dioxide (EtCO2). Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation. Method of measurement: Capnography.;Blood pressure. Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: The monitoring device.;Heart rate. Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: The monitoring device.;Oxygen saturation (SpO2). Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: Pulse oximeter.	—

Measure

Time frame

Partial pressure of carbon dioxide in arterial blood. Timepoint: 30 min after intubation. Method of measurement: Arterial blood gas (ABG).;PH. Timepoint: 30 min after intubation. Method of measurement: Arterial blood gas (ABG).;End-tidal carbon dioxide (EtCO2). Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation. Method of measurement: Capnography.;Blood pressure. Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: The monitoring device.;Heart rate. Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: The monitoring device.;Oxygen saturation (SpO2). Timepoint: Some minutes before laryngoscopy, during laryngoscopy, and then 15, 30, and 60 min after intubation, and after extubation in the recovery unit. Method of measurement: Pulse oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohre Nikeghbali

Bandare-abbas University of Medical Sciences

zohrenikeghbal77@gmail.com+98 76 3371 0393

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026