Comparison of the Effectiveness of Intranasal Ketamine, Intravenous Morphine Sulfate, and Intravenous Ketorolac in Reducing the Pain of the Renal Colic Patients in the Emergency Department of Shohadeye Ashayer Hospital of Khorramabad: A Randomized Controlled Trial

Comparison of the Effectiveness of Intranasal Ketamine, Intravenous Morphine Sulfate, and Intravenous Ketorolac in Reducing the Pain of the Renal Colic Patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230718058838N1

Enrollment

Registered

2023-07-20

Start date

2023-08-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal colic. Unspecified renal colic

Interventions

Intervention 1: Intervention group: Intranasal injection of 1mg/kg ketamine & 5cc intravenous normal saline. Intervention 2: Control group: Intravenous injection of 0.1mg/kg ketamine & 5cc intranasal

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: More than 18 years old Renal colic symptoms existence: unilateral or bilateral flank pain Sign of nephrolithiasis in CT scan or Ultrasound imaging

Exclusion criteria

Exclusion criteria: Pregnant female Opioid addiction Sensitivity to Morphine sulfate, Ketorolac or Ketamine Nasal obstruction Systolic blood pressure upper than 180mmHg or lesser than 90mmHg Respiratory distress Loss of conscious Patient with no enough cooperation Past medical history of GI bleeding Past medical history of Asthma Medication using during last 48hours

Design outcomes

Primary

Measure	Time frame
Pain severity in the renal colic patients. Timepoint: Before drug injection and 15, 30, 45 & 60 minute after injection. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mobin Nouredini

Khoram-Abad University of Medical Sciences

mobinnouredini@gmail.com+98 66 3335 1530

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026