female infertility. Female infertility of uterine origin
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: Granulocyte Colony Stimulating Factor (G-CSF), 300µg, single dose, subcutaneous, injected one hour before embryo transfer. Intervention 2: Contr
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Age less than 40 years maximum FSH level of 15 IU/ml repeated IVF failure absence of contraindications to receiving G-CSF (active infection, tuberculosis cycle disease, chronic neutropenia, history of malignancy in the past, current malignancy, renal failure, upper respiratory tract infection, congenital fructose intolerance) absence of any systemic diseases (hypertension, diabetes, antiphospholipid syndrome, lupus, thrombophilia and thyroid diseases)
Exclusion criteria
Exclusion criteria: Insufficient endometrial thickness (minimum 7 mm on the day of HCG injection) hypersensitivity to GCSF diagnosis of Asherman's syndrome diagnosis of polyps and fibroids by hysteroscopy refusal to participate in the study
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Transvaginal ultrasound. | — |
Primary
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate. Timepoint: two weeks after embryo transfer. Method of measurement: serum level of ß-HCG. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Ehsan Mousavi
Tabriz University of Medical Sciences
Outcome results
None listed