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Comparison of postoperative analgesic effect of intravenous acetaminophen versus intravenous caffeine in distal radius surgery

Comparison of postoperative analgesic effect of intravenous acetaminophen versus intravenous caffeine in distal radius surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230716058807N1
Enrollment
90
Registered
2023-08-01
Start date
2023-08-06
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

distal radius surgery. Fracture of lower end of radius

Interventions

Intervention 1: Intervention group: 10 mg/kg of injectable acetaminophen is diluted in 100 cc of normal saline and infused to the patient over 30 minutes. Intervention 2: Intervention group: 1 mg/kg o

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in research with informed consent after giving necessary and sufficient explanations about the study Age 20 to 60 years Distal radius fracture General anesthesia

Exclusion criteria

Exclusion criteria: Unwillingness to cooperate in the study Cardiac patients with a history of HTN (heart rate over 100 during surgery/blood pressure over 140 mm Hg during surgery) Occurrence of any problems and complications during the study Pregnancy, breastfeeding and abortion less than 3 months Allergy to acetaminophen/caffeine/morphine Long-term use of corticosteroids, antihistamines, narcotics and pain relievers Vision and hearing problems and other disabilities Chronic mental and physical illness (schizophrenia, diabetes, etc) Liver patients (hepatitis, cirrhosis, etc.) History of smoking, alcohol and drugs The duration of surgery should be less than 45 minutes

Design outcomes

Primary

MeasureTime frame
The amount and intensity of pain. Timepoint: 1, 3, 6 and 12 hours after the operation. Method of measurement: Using a ruler-like grading system (Visual Analog Scale) from 0 (no pain) to 10 (the most severe pain imaginable).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Talayeh

Qazvin University of Medical Sciences

hamed_talayeh@yahoo.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026