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Comparison of celecoxib versus acetaminophen as pre-emptive analgesics for the management of post operative pain after impacted mandibular third molar surgery

Comparison of celecoxib versus acetaminophen as pre-emptive analgesics for the management of post operative pain after impacted mandibular third molar surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230714058773N4
Enrollment
75
Registered
2023-10-10
Start date
2021-02-18
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Third molar surgery. Condition 2: Pain. Condition 3: Celecoxeb. Impacted teeth Pain, unspecified Other nonsteroidal anti-inflammatory drugs [NSAID]

Interventions

Intervention 1: Intervention group:35 patients received an oral dose of 200 mg of Celecoxeb 30 minutes before surgery. All operations were performed by the same surgeon and the efficacy of both drugs

Sponsors

Armed forces institute of dentistry CMH Rawalpindi
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 50 Years

Inclusion criteria

Inclusion criteria: Male and female aged from 17 to 50 years old Patients with at least one impacted mandibular third molar that is indicated for surgical extraction and also confirmed by periapical radiographs including mesioangular, distoangular, horizontal and vertical impactions Patients with no intake of analgesic and anti-inflammatory drugs for 1 week.

Exclusion criteria

Exclusion criteria: Patients with conditions in which the use of NSAIDs and COX-2 inhibitors is contraindicated. Patients with serious diseases like liver, kidney and cardiovascular diseases Pregnant or nursing women Patients with ulcers or bleeding in the digestive tract. Patients who are unable to express subjective discomfort symptoms. Patients with periodontal disease involving the adjacent teeth

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: 30 minutes before intervention and 4,6,8 hours after intervention. Method of measurement: The visual analogue scale comprised a horizontal line, 10cm in length with word descriptors at each endpoint, 0 at the left end presenting "no pain" and point 10 at the right end representing "worst possible pain.".

Countries

Pakistan

Contacts

Public ContactTehmina Maryam

Armed forces institute of dentistry CMH Rawalpindi

Tehminamaryam27@gmail.com+92 333 9576737

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026