Comparison of the effect of ephedrine, ketamine, ondansetron and atropine drugs to prevent nausea and vomiting during and after surgery in patients under spinal anesthesia

Comparison of the effect of ephedrine, ketamine, ondansetron and atropine drugs to prevent nausea and vomiting during and after surgery in patients under spinal anesthesia for lower limb fracture repair

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230713058769N1

Enrollment

128

Registered

2023-07-29

Start date

2023-09-23

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group 1: Before spinal anesthesia, they will receive 5 mg of ephedrine (Sterop belgium pharmaceutical company). In order to equalize the volume of the intervention drug in

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18-75 years old Both genders ASA class 1 and 2 Lower limb fracture repair surgery under spinal anesthesia Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of drug addiction History of seasonal allergies and allergies to any of the drugs used in this study Presence of neuromuscular diseases Presence of cardiomyopathy Presence of coagulopathy Presence of an underlying disease

Design outcomes

Primary

Measure	Time frame
Vomiting score according to the vomiting score table. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Number of times nausea occurs. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Severity of nausea according to visual analogue scale. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Vomiting score according to the vomiting score table. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Number of times nausea occurs. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Physical examination.;Severity of nausea according to visual analogue scale. Timepoint: In recovery, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Visual Analogue Scale.

—

Secondary

Measure	Time frame
The degree of sedation according to the RAMSAY SCORE. Timepoint: In recovery and 1, 2 and 4 hours after the operation. Method of measurement: RAMSAY SCORE.;Dosage of Metoclopramide. Timepoint: Within 24 hours after the operation. Method of measurement: Patient file.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamoddin Modir

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026