To determine effectiveness of topical application of 0.5% Timolol Maleate in treatment of chronic heel recalcitrant fissures

Efficacy of topical 0.5% Timolol Maleate in chronic recalcitrant heel fissures

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230712058759N1

Enrollment

150

Registered

2023-08-30

Start date

2023-06-12

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heel fissures, sheered heels, cracked heels, foot eczema. Xerosis cutis

Interventions

All the study patients will be advised to apply 2-3 drops of Timolol Maleate 0.5% on chronic, recalcitrant heel fissures over 2 weeks, A follow-up will be requested after 2 weeks and 4 weeks of applic

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients having heel, plantar fissures Ages between 18 to 75 years Both male and female

Exclusion criteria

Exclusion criteria: Patients taking oral beta blockers Known allergy to beta blockers Patients with known dermatoses affecting feet i.e. psoriasis, Reiter's syndrome, keratodermas etc

Design outcomes

Primary

Measure	Time frame
Measurement of Heel Fissures. Timepoint: 2 weeks and 4 weeks. Method of measurement: With the help of a ruler, heel fissures will be measured and marked with a water-soluble pen. Pictures will be taken to carry out the record of each follow-up and measuring of severity scale.	—

Countries

Pakistan

Contacts

Public ContactFurqan Khan

Pak Emirates Military Hospital

thepresidenthouse@gmail.com+92 51 9273440

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026