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the effect of rosuvastatin and calcitriol in total thyroidectomy

the effect of rosuvastatin and calcitriol on vocal function of total thyroidectomy patients: a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230711058741N1
Enrollment
159
Registered
2024-03-06
Start date
2024-03-20
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

voice problems after total thyroidectomy. Speech disturbances, not elsewhere classified

Interventions

Intervention 1: Intervention group A: rosuvastatin (Ropixon Abidipharm) tab 20 mg Q12hr plus calcitriol (Daanapharm) cap 0.25 mcg Q12hr for two weeks prior to surgery. Intervention 2: Intervention gro

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: All the patients who visited a thyroid clinic and a referral establishment in southwest Iran (Shiraz) age above 18 are due to undergone total thyroidectomy

Exclusion criteria

Exclusion criteria: patients who routinely use anti-inflammatory drugs (such as steroids), statins, or calcitriol patients who undergone partial thyroidectomy patients who undergone radical or lateral nuchal lymph-node dissection patients who refuse to participate in the study death of the patient patients who underwent previous nuchal surgeries patients who experience direct injury to the laryngeal nerves either during the surgery or during the thyroid biopsy procedure patients with underlying condition that directly affected their vocal functions (such as neurological conditions)

Design outcomes

Primary

MeasureTime frame
Voice handicap index (VHI) score. Timepoint: one month after surgery. Method of measurement: voice handicap index questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Yousefi

Shiraz University of Medical Sciences

m.r.yousefi.1319@gmail.com+98 71 3226 1971

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026