The outcome of Botox injection in the internal anal sphincter with and without ultrasound guided in children with constipation

Comparison of the outcome of botulinum toxin injection in internal anal sphincter under ultrasound guided with surface probe and without ultrasound in children with constipation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230704058661N1

Enrollment

Registered

2023-09-27

Start date

2023-10-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation. Constipation

Interventions

Intervention 1: Intervention group: In this group, botox injection in the sphincter of patients with ultrasound (ultrasound HONDA ELECTRONICS model HS-2600) with a surface probe (7.5 MHz) in the anus,

Eligibility

Sex/Gender

All

Age

3 Years to No maximum

Inclusion criteria

Inclusion criteria: Children over 3 years old with constipation Failure to respond to medical treatment and lifestyle changes by gastroenterologists The typical Hirschsprung appearance is not seen in the barium enema Presence of tuberculous ganglion in rectal biopsy No contraindications for botox injection Consent to participate in the study

Exclusion criteria

Exclusion criteria: Constipation caused by Hirschbrung Taking aminoglycoside drugs, penicillamine, quinine, and calcium channel blockers Having neuromuscular junction diseases such as myasthenia gravis

Design outcomes

Primary

Measure	Time frame
Improvement of constipation. Timepoint: Two weeks, one and three months after botox injection. Method of measurement: Biography of the child's parents.;Fecal incontinence. Timepoint: Two weeks, one and three months after botox injection. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Nazem

Esfahan University of Medical Sciences

m_nazem@med.mui.ac.ir+98 31 3386 6266

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026