The effect of vitamin B5 on stress; depression and anxiety

The effect of vitamin B5 administration compared to placebo on stress; depression; Anxiety, oxidative stress level and serum cortisol level in type 2 diabetes patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230702058641N2

Enrollment

Registered

2024-02-01

Start date

2024-01-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: vitamin B5 chewable tablet with a dose of 250 mg (produced by Shehab Pharmaceutical Company) once a day, which will be given to them along with metformin/insulin fo

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 30-65 years People who are not professional athletes. Receiving metformin/insulin. Patients should not take melatonin, aspirin, D3, omega3 during the study period. Not taking oral contraceptives in the last month people who have not received vitamin B supplements at least 3 months before the study.

Exclusion criteria

Exclusion criteria: Non-cooperation of patients to participate in the study Use of corticosteroids and anticoagulants in the last month Smokers The existence of congenital cognitive and anxiety diseases Incomplete completion of the questionnaire People taking combined oral hypoglycemic drugs such as Sinuripa tablets People taking drugs related to severe depression (bipolar) People taking vitamin B5 supplements before starting the tests

Design outcomes

Primary

Measure	Time frame
Score of depression. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of anxiety. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of stress. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.	—

Measure

Time frame

Score of depression. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of anxiety. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of stress. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.

—

Secondary

Measure	Time frame
Cortisol level. Timepoint: At the beginning of the study and after two months. Method of measurement: ELISA technique.;Nitric oxide levels. Timepoint: At the beginning of the study and after two months. Method of measurement: Gress method.;Malondialdehyde level. Timepoint: At the beginning of the study and after two months. Method of measurement: Thiobarbituric acid method.;Antioxidant capacity. Timepoint: At the beginning of the study and after two months. Method of measurement: FRAP measurement.	—

Measure

Time frame

Cortisol level. Timepoint: At the beginning of the study and after two months. Method of measurement: ELISA technique.;Nitric oxide levels. Timepoint: At the beginning of the study and after two months. Method of measurement: Gress method.;Malondialdehyde level. Timepoint: At the beginning of the study and after two months. Method of measurement: Thiobarbituric acid method.;Antioxidant capacity. Timepoint: At the beginning of the study and after two months. Method of measurement: FRAP measurement.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReihaneh Sadeghian

Shahre-kord University of Medical Sciences

reihaneh.sadeghian5@gmail.com+98 38 3334 9509

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026