sepsis. Systemic Inflammatory Response Syndrome of infectious origin with organ failureSevere sepsis
Conditions
Interventions
Intervention 1: Concomitant with the standard of care (fluid resuscitation, antibiotic therapy, management of electrolytes and acid-base disturbances and metabolic supports) patients will receive intr
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 89 Years
Inclusion criteria
Inclusion criteria: Age of 18–89 years Systolic blood pressure of 2 mmol/L SOFA score of =2 points consequent to the infection
Exclusion criteria
Exclusion criteria: Rejection of sepsis diagnosis after initial evaluations Decision to limit or withdraw treatment Steroid use within 4 weeks Chemotherapy for underlying malignancy within 4 weeks Etomidate use during hospitalization Pregnancy or lactation Informed written consent cannot be obtained from a patient or legal representative Corticosteroides contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to enter the septic shock. Timepoint: Every 1-hour. Method of measurement: According mean artrial pressure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasopressor requirement. Timepoint: Every 1-hour. Method of measurement: Starting a vasopressor drug (type and dose).;Need for mechanical ventilation support. Timepoint: Every 1-hour. Method of measurement: Patient intubation.;7-day mortality. Timepoint: 7 days after initial treatment. Method of measurement: patient follow-up.;28-day mortality. Timepoint: 28 days after initial treatment. Method of measurement: patient follow-up.;Length of stay in ICU. Timepoint: Daily. Method of measurement: patient follow-up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Emami
Tehran University of Medical Sciences
Outcome results
None listed