investigating the effect of probiotic supplements on blood pressure changes in patients undergoing hemodialysis at Namazi Hospital in Shiraz. Randomized clinical trial

investigating the effect of probiotic supplements on blood pressure changes in patients undergoing hemodialysis Randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230701058626N1

Enrollment

152

Registered

2023-11-30

Start date

2023-12-12

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis patients. Dependence on renal dialysis

Interventions

Intervention 1: Sachet containing probiotic L-Plantarum with a dose of 1*109, to be taken orally one sachet daily for 12 weeks. Intervention 2: A sachet containing the probiotic Streptococcus thermoph

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with chronic kidney disease who undergo hemodialysis for more than three months are included in the study

Exclusion criteria

Exclusion criteria: Active cancer Active infection Pregnancy Sensitivity to probiotic compounds

Design outcomes

Primary

Measure	Time frame
Arterial blood pressure. Timepoint: before and after treatment. Method of measurement: Arterial blood pressure of patients undergoing dialysis is taken and recorded in three stages before, during and after dialysis.	—

Secondary

Measure	Time frame
1. Determining the average arterial blood pressure before, during, and after receiving probiotics and placebo in experimental groups. Timepoint: before, during, and after receiving probiotics and placebo. Method of measurement: Digital pressure gauge.;Determining the average angiotensin-converting enzyme (ACE) activity before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average total antioxidative capacity (TAC), and total oxidative state (TOS) measure before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average complete blood count (CBC) before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Autolyzer.	—

Measure

Time frame

1. Determining the average arterial blood pressure before, during, and after receiving probiotics and placebo in experimental groups. Timepoint: before, during, and after receiving probiotics and placebo. Method of measurement: Digital pressure gauge.;Determining the average angiotensin-converting enzyme (ACE) activity before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average total antioxidative capacity (TAC), and total oxidative state (TOS) measure before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average complete blood count (CBC) before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Autolyzer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Karimi

Shiraz University of Medical Sciences

zkarimi@sums.ac.ir0098 71 3612261

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026