Patients with Calculus of kidney. Calculus of kidney
Conditions
Interventions
Intervention 1: Intervention group: Group A will receive dexmedetomidine (a vial CC2mcg/200 diluted with CC50 normal saline and infused over 10 minutes. This form of infusion will be repeated if neede
Sponsors
Dezfoul University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with kidney stones below 2cm and proximal ureter for ESWL aged 18 to 80 years with American Society of Anesthesiologists (ASA) physical status I, II or III who consent to participate in this study will be eligible for this study.
Exclusion criteria
Exclusion criteria: Patients who do not agree to participate in this study Patients with chronic liver failure Patients who have a history of allergy to this drug or other alpha-adrenergic drugs Patients with a history of bradycardia and low blood pressure Patients with coagulation disorders Patients with a history of allergy to drugs used to treat ESWL Patients with mental disorders, nervous disorders and skin disorders (inflammation). Patients with active infection Patients who are pregnant Patients who have uremia Patients with BMI > 25 Patients who have used painkillers 12 hours before visiting Patients who have pain before visiting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma level of Substance P in patients. Timepoint: At the beginning of the study and one week after lithotomy of the patients. Method of measurement: Measuring the Plasma level with ELISA.;Pain. Timepoint: At the beginning of the study and one week after lithotomy of the patients. Method of measurement: The person is shown a scale from 0 to 10 and the person gives a score from 0 to 10 on the level of pain felt. (Visual Analogue Scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: Manual sphygmomanometer.;Respiratory rate. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: clinical examination.;Nausea and Vomiting. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: Event occur. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Rajaeipour
Dezfoul University of Medical Sciences
Outcome results
None listed