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Evaluating the therapeutic effects of bromelain supplement on pain and inflammation parameters after orthodontic surgery

Evaluating the therapeutic effects of bromelain supplement on pain and inflammation parameters after orthodontic surgery: a randomized clinical trial.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230629058615N9
Enrollment
56
Registered
2025-07-21
Start date
2025-08-23
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-orthodontic care. Encounter for other specified aftercare

Interventions

Intervention 1: Intervention group: Included 28 patients older than 18 years who needed orthodontic treatment. After reviewing the inclusion and exclusion criteria of the study and obtaining informed

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Post-orthodontic patients Over 18 years old Ability to fill out an informed consent form Ability to follow the approved protocol for participating in the study

Exclusion criteria

Exclusion criteria: Mental and mood imbalance Use of painkillers and anti-inflammatories outside of the approved protocol Infection and formation of infectious cysts Occurrence of problems in patients that cause changes in their orthodontic status and others Has unstable vital signs Allergy to pineapple, celery, carrots, and fennel Pregnant and breastfeeding women Severe renal failure (GFR < 30) Severe liver failure (Child Pugh B, C) Having hemophilia Use of anticoagulant, antiplatelet, and thrombolytic drugs Patients with irregular heartbeat and tachycardia Asthma

Design outcomes

Primary

MeasureTime frame
Pain level. Timepoint: Days 1, 2, 3, and 7 following the orthodontic procedure. Method of measurement: Pain visual analogue scale (scoring in patient questionnaire).

Secondary

MeasureTime frame
The degree of inflammation and swelling of the gums. Timepoint: Days 1, 2, 3, and 7 following the orthodontic procedure. Method of measurement: Gingival index (scoring in patient questionnaire).;Side effects of Anaheal 500 GDU. Timepoint: Days 1, 2, 3, and 7 following the orthodontic procedure. Method of measurement: Ask the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Babakhanian

Islamic Azad University

sama.babakhani@gmail.com+98 21 2264 0051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026