Refractory gastro-esophageal reflux disease. Gastro-esophageal reflux disease without esophagitis
Conditions
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients with refractory GERD diagnosed by a gastroenterologist 2) Informed consent of the patient 3) Patients over 18 years old and under 65 years old
Exclusion criteria
Exclusion criteria: 1) Pregnancy or intention to become pregnant 2) Patients with erosive esophagitis or esophageal cancer 3) Patients with a history of upper gastrointestinal surgery 4) Patients suffering from anxiety disorders or panic attacks or other mental disorders 5) Patients who use prokinetics, histamine 2 receptor antagonists (H2RAs), proton pump inhibitors (PPIs), cholinergic, or anticholinergic agents within one month after registration. 6) Patients who have used a Helicobacter pylori eradication regimen within six months before registration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity and frequency of: 1) acid taste 2) movement of material 3) burning behind the breastbone 4) pain behind the breastbone 5) upper stomach pain 6) upper stomach burning. Timepoint: 24 hours, 48 hours, 7 days, and 14 days after the start of the study. Method of measurement: RDQ questionnaire, scoring from zero to five. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of sodium alginate, sodium bicarbonate, and calcium carbonate suspension. Timepoint: 24 hours, 48 hours, 7 days, and 14 days after the start of the study. Method of measurement: Ask the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadreza Ahmadi
Islamic Azad University
Outcome results
None listed