Evaluation of the therapeutic effects of bromelain-based supplement (Anaheal 1200 GDU enteric coated) after blepharoplasty

Evaluation of the therapeutic effects of bromelain-based supplement (Anaheal 1200 GDU enteric coated) on ecchymosis, swelling and pain after blepharoplasty in patients over 18 years old versus placebo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230629058615N5

Enrollment

Registered

2024-09-15

Start date

2024-10-22

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ptosis of eyelid. Unspecified ptosis of eyelid

Interventions

Intervention 1: Intervention group: includes 25 patients over 18 years old after blepharoplasty. After checking the inclusion and exclusion criteria of the study and obtaining informed consent, patien

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Post blepharoplasty surgery patients Age above 18 years Ability to fill out an informed consent form Ability to follow the approved protocol to participate in the study

Exclusion criteria

Exclusion criteria: Allergy to pineapple, celery, carrot and fennel Pregnant and breastfeeding women Severe kidney failure (GFR<30) Severe liver failure (Child pugh B, C) Haemophilia Use of anticoagulant, antiplatelet and thrombolytic drugs Patients with irregular heartbeat and tachycardia Asthma patients

Design outcomes

Primary

Measure	Time frame
The amount of ecchymosis after blepharoplasty. Timepoint: At 1, 3, 7 and 14 days after surgery. Method of measurement: Based on the questionnaire, the evaluation of the amount of periorbital ecchymosis and the scoring is based on the extent and severity of ecchymosis from 0 to 5.;The amount of swelling after blepharoplasty. Timepoint: At 1, 3, 7 and 14 days after surgery. Method of measurement: Based on the questionnaire, the evaluation of the amount of periorbital swelling and The scoring is based on the severity of swelling from 0 to 4.	—

Measure

Time frame

The amount of ecchymosis after blepharoplasty. Timepoint: At 1, 3, 7 and 14 days after surgery. Method of measurement: Based on the questionnaire, the evaluation of the amount of periorbital ecchymosis and the scoring is based on the extent and severity of ecchymosis from 0 to 5.;The amount of swelling after blepharoplasty. Timepoint: At 1, 3, 7 and 14 days after surgery. Method of measurement: Based on the questionnaire, the evaluation of the amount of periorbital swelling and The scoring is based on the severity of swelling from 0 to 4.

—

Secondary

Measure	Time frame
Side effects of Anaheal 1200 GDU. Timepoint: At 1 and 14 days after surgery. Method of measurement: Ask the patient.;The amount of pain after blepharoplasty. Timepoint: At 1, 3, 7 and 14 days after surgery. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDorsa sadat Miri

Islamic Azad University

dorsamiri792000@gmail.com+98 21 2264 0051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026