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The effect of Stop GnRH-agonist with Letrozole protocol in IVF cycles

The effect of Stop GnRH-agonist with Letrozole protocol on poor responders in IVF cycles

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230627058599N1
Enrollment
60
Registered
2024-09-11
Start date
2024-09-10
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with poor response in IVF cycles. Female infertility of other origin

Interventions

Intervention 1: Intervention group: In this group, GnRH agonist (triptorlin) is started at a dose of 0.1 mg daily from the 21st day of the previous cycle and continues until the onset of menstruation.

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 42 Years

Inclusion criteria

Inclusion criteria: Patients with a history of IVF failure who had three oocytes or less than three oocytes in the previous cycle. Patients with a history of IVF failure who, according to Poseidon criteria, are in the definition of poor ovarian responders.

Exclusion criteria

Exclusion criteria: Infertility due to male factor patients with endometriosis (stage 3 or 4) history of ovarian cyst surgery and PCOS patients hypogonadotropic hypogonadism chronic diseases

Design outcomes

Primary

MeasureTime frame
Number of mature follicles. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: vaginal ultrasound sonography.;The number of oocytes obtained. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: Observation (with a microscope) and counting of oocytes in the laboratory by an embryologist.;The quality of the obtained embryos. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: Observation (with a microscope) and examination in the laboratory by an embryologist.

Secondary

MeasureTime frame
Chemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: Blood test, measurement of BHCG titer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeila Majdi

Shahid Beheshti University of Medical Sciences

leilamajdi@rocketmail.com+98 21 2243 2560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026