Condition 1: sialadenitis. Condition 2: thyroid cancer. Sialoadenitis Carcinoma in situ of thyroid and other endocrine glands
Conditions
Interventions
Intervention 1: Intervention group: In this group, the patient will be injected at most 100 units of Botox (Masport-Iran), once in bilateral parotid glands two weeks before radioiodine therapy. Interv
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: radioiodine candidates due to thyroid carcinoma accepted informed consent first time of radioiodine therapy over 18 years old
Exclusion criteria
Exclusion criteria: history of systemic diseases affecting saliva production history of medications affecting saliva production history of surgeries on salivary glands or salivary glands dysfunction history of botox allergies or contreindication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Saliva voloum. Timepoint: before and 6 month after radioiodine therapy. Method of measurement: saliva collection by stipping in a collection tube every 30 seconds for 5 minutes.;Salivary gland appearance and tenderness. Timepoint: before and 6 month after radioiodine therapy. Method of measurement: physical examination.;Painful saliva production during eatinf meals. Timepoint: before, 2 weeks and 6 month after radioiodine therapy. Method of measurement: history taking.;Score of "Summated xerostomia inventory-Dutch version" questionnaire. Timepoint: before, 2 weeks and 6 month after radioiodine therapy. Method of measurement: "Summated xerostomia inventory-Dutch version" questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory and thyroid function tests. Timepoint: before and 6 month after radioiodine therapy. Method of measurement: laboratory assessments. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrshad Abbasi
Tehran University of Medical Sciences
Outcome results
None listed