Polyneuropathy. Drug-induced polyneuropathy
Conditions
Interventions
Intervention 1: Intervention group: Duloxetine drug is prescribed as 20 mg once a day and after two weeks the dose is increased to 40 mg a day. Intervention 2: Control group: Capsule containing starch
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: Signing the informed consent form of all the parents of the patients participating in this study regarding their participation in this study according to the approved protocol and the implementation of all orders and follow-ups. Patients with an age range between 5 and 18 years Cancer patients treated with vincristine Patients with cancer treated with vincristine who have complications and clinical symptoms of CIPN according to the clinical diagnosis of the relevant oncologist
Exclusion criteria
Exclusion criteria: The presence of other underlying polyneuropathies according to a normal basal muscle nerve strip CNS tumors Any cognitive disorder in patients with unstable medical condition Impaired vital signs at the time of assessment and muscle strip testing Consumption of nifedipine, cyclosporine, carbamazepine, phenytoin, HCSF, vitamin E, B6, B12, omega 3 and herbal medicines by the patient. Intolerance of the drug by the patient and declaration of non-cooperation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of neuropathy symptoms. Timepoint: After two months and also after six months from the start of the intervention. Method of measurement: Pediatric modified total neuropathy score questionnaire.;Examining emotional and behavioral symptoms. Timepoint: After two months and also after six months from the start of the intervention. Method of measurement: by the Strengths and Difficulties Questionnaire.;Examining the sensory function of nerves. Timepoint: After two months and also after six months from the start of the intervention. Method of measurement: by electro-diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of drug side effects (nausea and vomiting). Timepoint: Two months later and six months after the beginning of the intervention. Method of measurement: Questionnaire of occurrence of drug side effects. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Babaee
Shahid Beheshti University of Medical Sciences
Outcome results
None listed