Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: In addition to the second-generation antipsychotic drug (risperidone) that they have already taken, the patients receive two 3 mg melatonin tablets at the same time
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients admitted in the Psychiatric department of Ahvaz Golestan Hospital, who are in the age range of 16 to 65 years Diagnosis of schizophrenia based on DSM-5 criteria Informed consent of the patients or their guardian to participate in a research project Schizophrenic patients treated with risperidone
Exclusion criteria
Exclusion criteria: Taking typical and atypical antipsychotic drugs, except for Risperidone, antidepressants, Sodium valproate, and Lithium. Presence of comorbid psychiatric disorder (bipolar-psychotic, obsessive-compulsive disorder, post-traumatic stress disorder, eating disorder) Current or past diagnosis (last 6 months) of severe personality disorders that compromise the participant's ability to meet the requirements. Use of narcotic drugs or alcohol in the last 12 months, except for nicotine and caffeine Presence of mental retardation or other neurological cognitive disorders such as dementia, delirium, head trauma, seizures, obstructive sleep apnea. History of ECT in the past 6 months In case of serious complications, the patient will be excluded from the study. Hypersensitivity to Melatonin or any of the ingredients in the placebo Use of Clozapine or previous use of Melatonin based on medical history obtained Pregnancy , lactating women Diagnosing the depressive episode of schizophrenia based on the Calgary questionnaire
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive symptoms of schizophrenia. Timepoint: First, 4 and 6 weeks after the study. Method of measurement: Wechsler Memory Questionnaire, Cognitive impairment investigation via review of auditory verbal learning, Digit symbol substitution test, Fluency test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep-wake disorders. Timepoint: First, 4 and 6 weeks after the start of the study. Method of measurement: Pittsburgh Sleep Quality Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehrouzian Forouzan
Ahvaz University of Medical Sciences
Outcome results
None listed