multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: The intervention group (exercise) will be monitored for 8 weeks to start sports activities. In this way, two sessions of aerobic exercise per week using a stationar
Sponsors
Research Institute of Neuroscience, Faculty of Medical Sciences, Tehran
Eligibility
Sex/Gender
All
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: Male and female patients with MS with EDSS 1 to 4 Only patients using interferon-beta medication alone will participate in the study. Age range from 25 to 45 years Lack of regular physical activity in the last 6 months Ability to perform sports protocol
Exclusion criteria
Exclusion criteria: Worsening of the patient's condition Inability to complete the exercise protocol The beginning of the relapse period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MiR-155 , miR-326, miR-23b, miR-146a. Timepoint: Before starting the training program and 24 hours after the last training session. Method of measurement: RT-PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality. Timepoint: Before starting the training program and 24 hours after the last training session. Method of measurement: In order to measure the effect of the combined exercise program on the sleep quality of these patients, the Sleep Quality Questionnaire (PSQI) will be used.;Quality of Life. Timepoint: Before the start of the training program and after the end of the training program. Method of measurement: In order to measure the effect of the combined exercise program on the quality of life of these patients, the quality of life questionnaire of MS patients (MSQOL-54) will be used.;Fatigue rate. Timepoint: Before starting the training program and after it ends. Method of measurement: In order to measure the effect of the combined exercise program on the fatigue level of this patient, the comprehensive fatigue assessment scale in patients with MS (CFAB-MS) from the questionnaire related to fatigue in these patients will be used.;The amount of pain. Timepoint: Before starting the training program and after it ends. Method of measurement: The McGill Pain Questionnaire (SF-MPQ) will be used to measure the effect of the combined exercise program on the pain level of these patients.;EDSS. Timepoint: Before starting the training program and after its termination. Method of measurement: by a neurologist.;Time to get tired. Timepoint: Before starting the training program and after its termination. Method of measurement: 6 minute walk test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Torab
Tehran university
Outcome results
None listed