Metoclopramide versus erythromycin for the reduction of aspiration pneumonia in mechanically ventilated patients

Comparison of the effect of metoclopramide and erythromycin on aspiration pneumonia in intubated patients under mechanical ventilation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230618058512N1

Enrollment

150

Registered

2023-07-19

Start date

2023-07-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspiration pneumonia. Pneumonitis due to inhalation of food and vomit

Interventions

Intervention 1: Intervention group: Metoclopramide (Darou Pakhsh Co., Iran) 10 mg every 8 hours. Intervention 2: Intervention group: Erythromycin (Darou Pakhsh Co., Iran) 50 mg every 6 hours.

Eligibility

Sex/Gender

All

Age

17 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 17-70 years Intubated patients under mechanical ventilation Admitted to the ICU

Exclusion criteria

Exclusion criteria: Underlying pulmonary disease Pulmonary contusion Pulmonary emboli Pneumonia on admission Corticosteroid use Cardiopulmonary arrest Acute respiratory distress syndrome due to extrapulmonary causes end-stage renal disease

Design outcomes

Primary

Measure	Time frame
Aspiration pneumonia rate. Timepoint: Up to 72 hours after initiation of treatment. Method of measurement: Clinical Pulmonary Infection Score (CPIS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Sarafikhah

Bandare-abbas University of Medical Sciences

dr.sarafikhah@gmail.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026