Sublingual and buccal misoprostol in the first trimester abortions

Comparison of buccal and sublingual misoprostol administration in first trimester abortions: a clinical trial study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230617058504N1

Enrollment

300

Registered

2024-03-13

Start date

2024-03-20

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical abortion of the first trimester. Medical abortion

Interventions

Intervention 1: Intervention group 1: Recipient of sublingual misoprostol : In this group of patients, 4 tablets of misoprostol 200 are taken sublingually every 3 hours up to three times a day. Interv

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Abortion indication in the first trimester (including legal abortion, missed abortion, incomplete induced abortion) Signing informed consent

Exclusion criteria

Exclusion criteria: Allergy to misoprostol Previous history of cesarean section

Design outcomes

Primary

Measure	Time frame
Percentage of treatment failure. Timepoint: 24 hours post-intervention. Method of measurement: Evaluation of the complete excretion of the product of pregnancy through clinical history and examination and in case of uncertainty, through ultrasound.	—

Secondary

Measure	Time frame
Misoprostol side effects. Timepoint: Immediately after , 6, 24 and 48 hours post-intervention. Method of measurement: Clinical history and examination.;Lenght of hospitalization. Timepoint: Time of discharge. Method of measurement: Based on the information of the medical records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojgan Mokhtari

Iran University of Medical Sciences

mokhtari.m@iums.ac.ir+98 21 6655 2972

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026