The effect of high-dose nitroglycerin injection in patients with acute pulmonary edema

Investigating the effect of high-dose nitroglycerin injection in patients with acute pulmonary edema

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230612058465N2

Enrollment

100

Registered

2024-06-20

Start date

2024-03-11

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decompensated Heart failure. Heart failure

Interventions

Intervention 1: Receive high dose TNG(100 micro per minute). Intervention 2: Receive usual TNG( 4 micro per minute).

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with chief complaint of dyspnea due to decompensated heart failure vascular type ( orthopnea, fine crackle on auscultation, raised JVP)

Exclusion criteria

Exclusion criteria: hypotension recent myocardial infarction history of allergy to TNG patients who need intubation on admission

Design outcomes

Primary

Measure	Time frame
Reduce blood pressure and dyspnea. Timepoint: q 5 minutes up to 1-hour. Method of measurement: For blood pressure use mmHg, and for reduce dyspnea use Likert scale.	—

Secondary

Measure	Time frame
Intubation. Timepoint: 1-hour after admission. Method of measurement: Intubation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElnaz Vafadar Moradi

Mashhad University of Medical Sciences

Vafadarme@mums.ac.ir+98 51 3854 3031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026