The effect of misoprostol alone and misoprostol together with vaginal estrogen in induction of labor

Comparison of the effect of misoprostol alone and misoprostol together with vaginal estrogen in preparing the cervix and induction of labor in term pregnancies

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230611058454N1

Enrollment

200

Registered

2023-06-24

Start date

2023-07-23

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor induction. Failed medical induction of labor

Interventions

Intervention 1: Intervention group: For termination of pregnancy, 25 micrograms of misoprostol is placed sublingual. According to the uterine contractions, every 3 to 6 hours, 25 micrograms of misopro

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Term pregnancy (Gestational age >37 weeks) Nulliparous woman Singleton pregnancy Alive Fetus with cephalic presentation Bishop score < 5

Exclusion criteria

Exclusion criteria: Misoprostol or estrogen contraindication Women with a history the uterus surgery Women with a history or family history of thromboembolism

Design outcomes

Primary

Measure	Time frame
Interval from induction with misoprostol to the attainment of 6 cm cervical dilation. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.;Interval from 6 cm cervical dilation to full cervical dilation. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.;Interval from full cervical dilation to active phase of labor. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.	—

Measure

Time frame

Interval from induction with misoprostol to the attainment of 6 cm cervical dilation. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.;Interval from 6 cm cervical dilation to full cervical dilation. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.;Interval from full cervical dilation to active phase of labor. Timepoint: Once, after delivery. Method of measurement: Information entered in the patient's delivery record.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Golshahi

Tehran University of Medical Sciences

fgolshahi@yahoo.com+98 21 4216 0852

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026