Evaluation of the release amount of chitosan and the effect of it on the pH of saliva after consuming chitosan-based gum

Evaluation of the release amount of chitosan and the effect of it on the pH of saliva after consuming chitosan-based gum: a clinical trial study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230611058451N1

Enrollment

Registered

2023-07-30

Start date

2023-09-15

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries. Dental caries

Interventions

Intervention group: a piece of chewing gum containing 20% chitosan made by Shoko Prasto company, which will be chewed for 30 minutes..

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Have good oral hygiene. Have at least 24 healthy teeth (5 teeth in each quadrant of the jaw).

Exclusion criteria

Exclusion criteria: Has antibiotics in the last 6 months. Being a smoker. Using mouthwash. Having systemic disease. Having any sign of periodontal disease. Having an orthodontic device or any prothesis in his/her mouth.

Design outcomes

Primary

Measure	Time frame
Quantification of chitosan released in saliva. Timepoint: Measuring the amount of chitosan in saliva 10, 20 and 30 minutes after starting to consume gum. Method of measurement: Ninhydrin Method.;PH of saliva. Timepoint: Measuring saliva pH before the intervention and 10, 20 and 30 minutes after the start of chewing gum. Method of measurement: Strip Method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohadese Shokripour

Hamedan University of Medical Sciences

shokripour557@gmail.com+98 81 3131 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026