Skip to content

Effect of probiotic prophylaxis on ventilator-associated pneumonia

Effect of probiotic prophylaxis on the prevention of ventilator-associated pneumonia (VAP) in patients admitted to the intensive care unit (ICU)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230611058449N1
Enrollment
134
Registered
2023-06-27
Start date
2023-06-19
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: Patients over 18 years of age and intubated with mechanical ventilation randomly placed in the intervention group of this study will use BioIBS probiotic capsules p
Oral hygiene of the patient with chlorhexidine mouthwash
Cessation of sedation during daily periods and waking the patient up
Daily periods of spontaneous breathing of the patient. Intervention 2: Control group: Patients over 18 years of age and intubated and connected to mechanical ventilation were randomly placed in the co

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients over the age of 18 that are intubated in the intensive care unit

Exclusion criteria

Exclusion criteria: Diagnosis was ventilator-associated pneumonia from beginning Diagnosis was pneumonia from beginning Pregnancy Prosthetic heart valves Prosthetic vascular grafts Immunosuppress History of rheumatic fever History of gastrointestinal tract injury in the current hospitalization Having tracheostomy Lack of consent of the patient or her or his parents Gavage intolerance

Design outcomes

Primary

MeasureTime frame
Clinical Pulmonary Infection Score. Timepoint: Clinical Pulmonary Infection Score at the beginning of the study and the third day after probiotic consumption. Method of measurement: Clinical Pulmonary Infection Score using ; body temperature ; leukocyte count and morphology , tracheal secretion volume and character , PaO2/FiO2 values , presence of pulmonary infiltration ; Tracheal aspirate culture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Nazembokaee

Shahid Beheshti University of Medical Sciences

ali_nb@yahoo.com+98 21 2610 5050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026