The effect of probiotics on patients with end-stage renal failure

Evaluation of the effect of probiotic consumption on acidosis in patients with chronic kidney failure (CKD) with end stage renal disease (ESRD) whom referred to Luqman Hakim Hospital from September 2023 to Mars 2024

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230608058421N1

Enrollment

Registered

2023-06-29

Start date

2023-08-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease. Chronic kidney disease (CKD)

Interventions

Intervention 1: Intervention group: Probiotic group, patients in this group will be advised to take probiotic capsules orally every day after lunch for three months. The medicine used will be Cap Lact

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The age of entering the study is considered between 18 and 60 years. Confirmation of chronic kidney failure from the patient's tests or documents that show a structural or functional disorder, or in other words, albuminuria or creatinine drop. More than three months have passed since the mentioned disorders. Affected patients should be under the same dialysis machines and similar filters.

Exclusion criteria

Exclusion criteria: History of kidney transplant Any possible cause other than CKD for creatinine drop Other causes of metabolic acidosis such as diarrhea, heart failure or shock Metformin use Taking blood pressure lowering medications due to the possibility of acidosis

Design outcomes

Primary

Measure	Time frame
Arterial blood pH. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.;Arterial blood HCO3. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.	—

Measure

Time frame

Arterial blood pH. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.;Arterial blood HCO3. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.

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Secondary

Measure	Time frame
Serum creatinine level. Timepoint: Before intervention and 3 months after intervention. Method of measurement: It will be assessed by the Pars Azmoon kit in the laboratory of Luqman Hakim Hospital.;Glomerular filtration rate. Timepoint: Before intervention and 3 months after intervention. Method of measurement: eGFR (mL/min)= [(140 - age) × Wt / (0.814 × Serum Creatinine level in µmol/L)] × (0.85 if female).	—

Measure

Time frame

Serum creatinine level. Timepoint: Before intervention and 3 months after intervention. Method of measurement: It will be assessed by the Pars Azmoon kit in the laboratory of Luqman Hakim Hospital.;Glomerular filtration rate. Timepoint: Before intervention and 3 months after intervention. Method of measurement: eGFR (mL/min)= [(140 - age) × Wt / (0.814 × Serum Creatinine level in µmol/L)] × (0.85 if female).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Futuhi

Shahid Beheshti University of Medical Sciences

ff.1975@yahoo.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026