the effect of iron supplementation and pregnancy outcomes

Investigating the effect of iron supplementation and pregnancy outcomes in women with a history of infertility

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230607058400N2

Enrollment

112

Registered

2024-09-01

Start date

2024-08-20

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy. 026

Interventions

Intervention 1: Intervention Group: The iron supplement will contain 65 mg of elemental iron, which is the standard dose of iron supplement recommended for pregnant women in Iran. The participants are

Eligibility

Sex/Gender

Female

Age

20 Years to 39 Years

Inclusion criteria

Inclusion criteria: Married women with infertility complaints aged 20 to 39 years Confirmed infertility by definition (at least 12 months of frequent unprotected intercourse trying to conceive) IVF/ICSI candidate and having at least one grade A embryo AMH between 1 to 4.5 Referral for the first or second embryo transfer Consent to participate in the study

Exclusion criteria

Exclusion criteria: Women with a history of hematopoiesis with iron deficiency or iron deficiency anemia (hemoglobin less than 12, ferritin less than 15 and TIBC more than 380) Confirmed endometriosis At least three failures in the previous implantations (RIF) Uterine adenomyosis or myomatosis If the couple's infertility is related to Tese

Design outcomes

Primary

Measure	Time frame
Endometrial thickness. Timepoint: 3 months, before each time of intervention and before each time of transfer up to three times. Method of measurement: Ultrasound machine.;The quality of embryos. Timepoint: 3 months, after each puncture. Method of measurement: Examination of the grade of the embryos is done on the 3rd or 5th day after the puncture and fertilization. During the examination by the light microscope of the embryos based on the quality of the internal cell mass (ICM), the embryos are classified from grade A to C, and grade A embryos have the best quality.;Number of embryos. Timepoint: 3 months, after each puncture. Method of measurement: by counting under a light microscope.;Positive beta HCG. Timepoint: 3 months, 2 weeks after each transfer. Method of measurement: With a blood test and measuring the amount of placental gonadotropin hormone in the blood, which is more than 5 is a positive sign of this test.	—

Measure

Time frame

Endometrial thickness. Timepoint: 3 months, before each time of intervention and before each time of transfer up to three times. Method of measurement: Ultrasound machine.;The quality of embryos. Timepoint: 3 months, after each puncture. Method of measurement: Examination of the grade of the embryos is done on the 3rd or 5th day after the puncture and fertilization. During the examination by the light microscope of the embryos based on the quality of the internal cell mass (ICM), the embryos are classified from grade A to C, and grade A embryos have the best quality.;Number of embryos. Timepoint: 3 months, after each puncture. Method of measurement: by counting under a light microscope.;Positive beta HCG. Timepoint: 3 months, 2 weeks after each transfer. Method of measurement: With a blood test and measuring the amount of placental gonadotropin hormone in the blood, which is more than 5 is a positive sign of this test.

—

Secondary

Measure	Time frame
Side effects of medication. Timepoint: 3 months, in two-week intervals of visits. Method of measurement: Check list by follow ups.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactelena nakhaei

Gorgan University of Medical Sciences

dr.elena.nakhaei@gmail.com+98 911 275 5811

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026