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The effect of epinephrine nebulizer with subcutaneous injection in patients with acute asthma attack

Comparison of the effect of epinephrine nebulizer with subcutaneous injection in patients with acute asthma attack: a randomized clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230606058389N1
Enrollment
66
Registered
2023-07-10
Start date
2023-07-06
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Status asthma. Unspecified asthma with status asthmaticus

Interventions

Intervention 1: Intervention group: Children with an acute asthma attack that has not responded to standard treatments. Children with an acute attack referred to the emergency room of Akbar, Qaim or S

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 14 Years

Inclusion criteria

Inclusion criteria: Children with acute asthma attacks referred to the emergency of Akbar's children, Qaem or Dr. Sheikh hospitals who have not responded to the initial stages of standard asthma treatment, including bronchodilator oxygen, Atrovent, and injectable corticosteroids with appropriate doses.

Exclusion criteria

Exclusion criteria: Children with asthma with conventional treatment response Children over 14 years old Children with asthma due to another side effect

Design outcomes

Primary

MeasureTime frame
Number of breaths per minute according to age,. Timepoint: The time interval before the visit and one hour after receiving subcutaneous epinephrine or epinephrine bolus. Patients will be visited and examined by the on-call resident during their hospitalization. Method of measurement: Subcutaneous injection of epinephrine with a dose of 0.01 cc of 1.1000 solution or nebulization of epinephrine in the form of nebulization of two ampoules of epinephrine 1.1000 which will be placed after adding normal saline to the appropriate volume for nebulization.;Expiratory - inspiratory wheezing. Timepoint: The time interval before the visit and one hour after receiving subcutaneous epinephrine or epinephrine bolus. Patients will be visited and examined by the on-call resident during their hospitalization. Method of measurement: Subcutaneous injection of epinephrine with a dose of 0.01 cc of 1.1000 solution or nebulization of epinephrine in the form of nebulization of two ampoules of epinephrine 1.1000 which will be placed after adding normal saline to the appropriate volume for nebulization.;Use of respiratory secondary muscles. Timepoint: The time interval before the visit and one hour after receiving subcutaneous epinephrine or epinephrine bolus. Patients will be visited and examined by the on-call resident during their hospitalization. Method of measurement: Subcutaneous injection of epinephrine with a dose of 0.01 cc of 1.1000 solution or nebulization of epinephrine in the form of nebulization of two ampoules of epinephrine 1.1000 which will be placed after adding normal saline to the appropriate volume for nebulization.;Oxygen saturation according to the Pulmonary Index score table. Timepoint: The time interval before the visit and one hour after receiving subcutaneous epinephrine or epinephrine bolus. Patients will be visited and examined by the on-call resident during their hospitalization. Method of measurement: The treatment steps for asthma symptoms will be carefully ch

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Javad Seyedi

Mashhad University of Medical Sciences

mobinmdl94@gmail.com+98 910 171 6090

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026