melatonin in neonates with hypoxic encephalopathy

Investigating the effect of melatonin in pro-oxidant antioxidant balance of neonates with hypoxic ischemic encephalopathy: A Randomized Parallel Clinical Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230605058385N1

Enrollment

Registered

2023-09-02

Start date

2023-09-01

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoxic ischemic encephalopathy [HIE]. Hypoxic ischemic encephalopathy [HIE]

Interventions

Intervention 1: Intervention group: infants suffered from hypoxic ischemic encephalopathy who receive Melatonin ( 10 mg/kg/day, orally for 5 days). Intervention 2: Control group: infants suffered from

Eligibility

Sex/Gender

All

Age

No minimum to 10 Days

Inclusion criteria

Inclusion criteria: neonates with pregnancy age more than 32 weeks diagnosis hypoxic ischemic encephalopathy parent consent

Exclusion criteria

Exclusion criteria: congenital malformations congenital infections maternal chorioamnionitis heretical encephalopathy metabolic encephalopathy hyperbilirobinemic encephalopathy

Design outcomes

Primary

Measure	Time frame
Pro-Oxidant Antioxidant Balance. Timepoint: three days after birth. Method of measurement: Pro-Oxidant Antioxidant Balance (PAB) assay.	—

Secondary

Measure	Time frame
Pro-Oxidant Antioxidant Balance. Timepoint: seven days after birth. Method of measurement: Pro-Oxidant Antioxidant Balance (PAB) assay.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contact??? ????????

Mashhad University of Medical Sciences

Boskabadih@mums.ac.ir+98 51 3801 2469

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026