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Efficacy of oral itraconazole with sertaconazole cream versus oral itraconazole with clotrimazole cream in dermatophytosis - a randomized controlled trial in a tertiary care hospital in Pakistan

Efficacy of oral itraconazole with sertaconazole cream versus oral itraconazole with clotrimazole cream in dermatophytosis - a randomized controlled trial in a tertiary care hospital in Pakistan

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230531058353N1
Enrollment
118
Registered
2023-08-07
Start date
2023-06-26
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatophyte infection. Dermatophytosis

Interventions

Intervention 1: Intervention group: In group "A", patients were treated with Tab Itraconazole 100mg twice a day and sertaconazole cream applied topically twice a day for 4 weeks or less in patients in

Sponsors

PNS Shifa
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients of both, male and female genders, in age group 12-75 years with clinical manifestations of cutaneous dermatophyte infections (tinea corporis/tinea cruris/tinea faciei) and confirmation done with skin scraping positive for potassium hydroxide (KOH) mount.

Exclusion criteria

Exclusion criteria: Patients with age less than 12 years and greater than 75 years. Hyperlipidemia Abnormal liver function tests Pregnant and breast feeding females. solitary lesion which is less than 3 cm in diameter hypersensitivity to antifungals if patients are on any systemic medications known to have interactions with itraconazole superadded bacterial infections patients on immunosuppressive drugs patients who are known case of liver or renal disease Tinea capitis and onychomycosis

Design outcomes

Primary

MeasureTime frame
Clinical evaluation and absence of fungal hyphae on KOH microscopy. Timepoint: Patients were evaluated clinically on 2 weeks of treatment then 4 weeks of treatment (end point) and then further followed up after 4 weeks. Method of measurement: Clinical evaluation.

Countries

Pakistan

Contacts

Public ContactDr Absha Abbasi

PNS Shifa

abshaabbasi5@gmail.com+92 21 48506592

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026