Exosome and stem cells therapy

Investigating the effect of injecting the combination of exosomes extracted from follicular fluid, stem cells extracted from Wharton's jelly, platelets enriched from blood plasma and gonadotropins into the ovaries of poi, pof patients.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230528058312N3

Enrollment

Registered

2024-02-19

Start date

2024-02-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature Ovarian failure(POF) / Premature Ovarian Insufficiency (POI). Female infertility associated with anovulation

Interventions

Intervention 1: Intervention group: Infertile women with primary or secondary amenorrhea for more than 4 months under 40 years old with an elevated serum level of FSH (higher than 25 mIU/mL).This grou

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women with premature menopause POF Women with premature ovarian failure POI Normal women with Grade A eggs

Exclusion criteria

Exclusion criteria: Women with idiopathic infertility Women with adequate ovarian reserve

Design outcomes

Primary

Measure	Time frame
Absence of eggs in the ovaries of women under 40 years and primary or secondary amenorrhea for more than 4 months in women under 40 years with an elevated serum level of Follicular Stimulated Hormone(higher than 25 mIU/mL. Timepoint: 15 days after the injection and then every month at the time of ovulation during one year. Method of measurement: Transvaginal ultrasound device, Hormonal Test by Elisa Kit.	—

Measure

Time frame

Absence of eggs in the ovaries of women under 40 years and primary or secondary amenorrhea for more than 4 months in women under 40 years with an elevated serum level of Follicular Stimulated Hormone(higher than 25 mIU/mL. Timepoint: 15 days after the injection and then every month at the time of ovulation during one year. Method of measurement: Transvaginal ultrasound device, Hormonal Test by Elisa Kit.

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Secondary

Measure	Time frame
Absence of eggs in the ovaries of women under 40 years and primary or secondary amenorrhea for more than 4 months in women under 40 years with an elevated serum level of Follicular Stimulated Hormone(higher than 25 mIU/m. Timepoint: 15 days after the injection and then every month at the time of ovulation during one year. Method of measurement: Transvaginal ultrasound device, Hormonal Test by Elisa Kit.	—

Measure

Time frame

Absence of eggs in the ovaries of women under 40 years and primary or secondary amenorrhea for more than 4 months in women under 40 years with an elevated serum level of Follicular Stimulated Hormone(higher than 25 mIU/m. Timepoint: 15 days after the injection and then every month at the time of ovulation during one year. Method of measurement: Transvaginal ultrasound device, Hormonal Test by Elisa Kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Reza Tabatabaee Qomi

Tahoora infertility treatment and lmited surgury clinic

taba_1359@yahoo.com+98 25 3725 4719

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026