Exosome and stem cells therapy

Investigating the effect of exosome injection extracted from seminal plasma, stem cells derived from Wharton's testosterone gel and FSH on the process of spermatogenesis in NOA individuals.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230528058312N2

Enrollment

Registered

2024-02-07

Start date

2024-02-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-obstructive azoospermia. Male infertility

Interventions

Intervention 1: Intervention group: This group receives only 50 microliters of exosomes extracted from the semen of healthy people. Semen samples are collected in the Andrology Laboratory of Tahura In

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: People who do not have sperm in their semen samples (Azoospermia) will be selected. In order to exosome extraction from seminal plasma, people who have normal semen samples (according to global standards (WHO)) will be selected.

Exclusion criteria

Exclusion criteria: People with obstructive azoospermia Azoospermia whose testicular tissue biopsy did not show germ cells

Design outcomes

Primary

Measure	Time frame
Absence of sperm, observation of germ cells in testicular tissue pathology. Timepoint: 3 months after the injection of stem cells, exosome, FSH, testosterone. Method of measurement: Siemens analysis, TESE surgery.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactseyed Reza Tabatabaee Qomi

Tahoora infertility treatment and lmited surgury clinic

taba_1359@yahoo.com3747113135

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026