Investigating the effect of eight weeks of low-intensity endurance training with lower limb blood flow restriction on arterial blood pressure and cardiac function in patients with mild hypertension

Investigating the effect of eight-week low-intensity endurance training with lower limb blood flow restriction on arterial blood pressure, heart performance, and serum levels of PGC1-a, Klotho, and nitric oxide metabolites in patients with mild hypertension

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230528058311N1

Enrollment

Registered

2023-06-12

Start date

2023-06-10

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Method of treaning to prevent high blood pressure and diminish the need to consume antihypertensive drugs..

Interventions

Intervention 1: Intervention group: a group that rides a stationary bicycle at 50% VO2paek for 3 sessions a week, every other day, and each session is a maximum of 45 minutes for 8 weeks. Intervention

Eligibility

Sex/Gender

All

Age

50 Years to 65 Years

Inclusion criteria

Inclusion criteria: 50 - 64 years old Body mass index (BMI) less than 30 Not consumption of blood pressure drugs systolic blood pressure: 130-150mmHg ; diastolic blood pressure>80 mmHg

Exclusion criteria

Exclusion criteria: Secondary hypertension Smoking Heart, respiratory, kidney, liver, metabolic, and other chronic diseases

Design outcomes

Primary

Measure	Time frame
Serum PGC1a level. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Elisa.;Serum levels of Klotho. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Elisa.;Serum nitrite levels. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Photometry.	—

Measure

Time frame

Serum PGC1a level. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Elisa.;Serum levels of Klotho. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Elisa.;Serum nitrite levels. Timepoint: Before starting training and 24 hours after the last training session. Method of measurement: Photometry.

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Secondary

Measure	Time frame
Changes in blood pressure. Timepoint: One week after the intervention. Method of measurement: with a mercury barometer.;Left ventricular ejection fraction. Timepoint: One week after the intervention. Method of measurement: Echocardiography by a cardiologist.;Changes in biochemical parameters. Timepoint: One week after the intervention. Method of measurement: Elisa.;Left ventricular fractional shortening. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular mass. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Posterior wall thickness. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Relative wall thickness. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Isovolumic relaxation time. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Mean left atrial pressure. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular end-systolic diameter. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular end-diastolic diameter. Timepoint: One week after the intervention. Method of measurement: Echocardiography.	—

Measure

Time frame

Changes in blood pressure. Timepoint: One week after the intervention. Method of measurement: with a mercury barometer.;Left ventricular ejection fraction. Timepoint: One week after the intervention. Method of measurement: Echocardiography by a cardiologist.;Changes in biochemical parameters. Timepoint: One week after the intervention. Method of measurement: Elisa.;Left ventricular fractional shortening. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular mass. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Posterior wall thickness. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Relative wall thickness. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Isovolumic relaxation time. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Mean left atrial pressure. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular end-systolic diameter. Timepoint: One week after the intervention. Method of measurement: Echocardiography.;Left ventricular end-diastolic diameter. Timepoint: One week after the intervention. Method of measurement: Echocardiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSiavash Jokar

Kerman University of Medical Sciences

Sjokar@gmail.com+98 34 3132 0500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026