Comparison of the effects of clonidine and tranexamic acid on the amount of bleeding during tympanoplasty

Comparison between effect of oral clonidine and tranexamic acid on bleeding during tympanoplasty surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230523058274N1

Enrollment

Registered

2023-07-07

Start date

2023-07-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Tympanoplasty. Condition 2: Hemorrhage. Cellulitis of external ear, unspecified ear Hemorrhage, not elsewhere classified

Interventions

Intervention 1: Intervention group: 90 minutes before the operation, 200 micrograms of clonidine was administered to one group. Intervention 2: Intervention group: 90 minutes before the operation for

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 60 are candidates for tympanoplasty

Exclusion criteria

Exclusion criteria: Treated with tricyclic antidepressants or monoamine oxidase inhibitors Patients with heart, liver, kidney diseases and severe mental disorders Patients with systolic blood pressure above 160 mmHg and diastolic blood pressure above 90 mmHg. Heart rate less than 50 per minute

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: During tympanoplasty surgery. Method of measurement: A 4-point scoring system was evaluated, 0 = no bleeding, 1 = brief (suction rarely), 2 = heavy bleeding (frequent suction) and 3 = very heavy bleeding (conditions of surgical problem and continuous suction).;Hemodynamic variables. Timepoint: It was recorded every 10 minutes before and after pre-drug injection, after induction of anesthesia, after intubation, before surgery and then during surgery. Method of measurement: ???? ????????.	—

Measure

Time frame

Bleeding. Timepoint: During tympanoplasty surgery. Method of measurement: A 4-point scoring system was evaluated, 0 = no bleeding, 1 = brief (suction rarely), 2 = heavy bleeding (frequent suction) and 3 = very heavy bleeding (conditions of surgical problem and continuous suction).;Hemodynamic variables. Timepoint: It was recorded every 10 minutes before and after pre-drug injection, after induction of anesthesia, after intubation, before surgery and then during surgery. Method of measurement: ???? ????????.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Izadabadi

Shiraz University of Medical Sciences

fatemehizadabadi@gmail.com+98 917 687 7023

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026