covid 19. U09
Conditions
Interventions
Intervention 1: Intervention group: They are treated with pentoxifylline 400 mg three times a day along with intravenous dexamethasone 4 mg every 12 hours. Intervention 2: Control group: They are trea
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnosis of covid in the last 24 to 48 hours Candidate for hospitalization (o2sat24 or Pao2/Fio2<300) Covid-19 patients who are candidates for hospitalization with indications for hospitalization according to the country's guidelines, who had pulmonary infiltration in CT scan Outpatients with pulmonary infiltration on CT scan Age 18 to 70 years
Exclusion criteria
Exclusion criteria: Patients who were treated with Coltera (lupinavir/ritonavir). Patients with shock or hemodynamic instability Drug intolerance Patients with a history of Crohn's or ulcerative colitis, diarrhea or chronic malabsorption Neuromuscular diseases GFR less than 30 ml/min History of cirrhosis, hepatitis and severe liver diseases Patients receiving chemotherapy for cancer Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery. Timepoint: It is evaluated during the first 72 hours after hospitalization and the start of the intervention. Method of measurement: It is evaluated in the form of arterial blood oxygen level of at least 93%, cessation of fever for 72 hours and improvement of the general condition through a questionnaire.;IL-6. Timepoint: At the start of treatment and after one week from the start of treatment. Method of measurement: kit.;CRP. Timepoint: At the start of treatment and after one week from the start of treatment. Method of measurement: kit.;ESR. Timepoint: At the start of treatment and after one week from the start of treatment. Method of measurement: KIT.;Ferritin. Timepoint: At the start of treatment and after one week from the start of treatment. Method of measurement: kit.;Involvement in HRCT. Timepoint: At the start of treatment and after one week from the start of treatment. Method of measurement: Using CT SCAN observation and evaluation by a lung specialist.;Hospitalization in ICU. Timepoint: During the course of treatment. Method of measurement: CHECKLIST.;Death. Timepoint: During the course of treatment. Method of measurement: CHECKLIST. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Falahati marvast
Yazd University of Medical Sciences
Outcome results
None listed