Peripheral polyneuropathy in type 2 diabetes. Type 2 diabetes mellitus with diabetic polyneuropathy
Conditions
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Inclusion criteria
Inclusion criteria: Men and women between the ages of 20 and 85 Having type 2 diabetes (whose type 2 diabetes has already been proven by tests of FBS > 126 and HbA1c > 6.5 and they are being treated with oral antidiabetic drugs or insulin) Having the symptoms of distal peripheral polyneuropathy: feeling pain and excessive sensitivity or reduced sensation or feeling of burning, tingling and murmur in the hands or feet of the patient
Exclusion criteria
Exclusion criteria: Suffering from other neuropathies other than diabetic neuropathy Neuromuscular diseases (such as myasthenia gravis) Magnesium level above 2.1 History of magnesium consumption in the last 3 months A history of persistent diarrhea and vomiting History of diuretic use with a dose of more than 40 mg History of thyroid diseases or levothyroxine use History of heart block or use of calcium channel blockers Having chronic kidney disease (GFR<60) Taking antidepressants, anticonvulsants, or analgesics Pregnancy and breastfeeding History of any malignancy History of amputation or active diabetic foot ulcer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vibration sensation. Timepoint: Before the intervention and 1 and 2 months after the intervention. Method of measurement: Duration of perception of vibration sensation in the big toe of both feet after the 128 Hz diapason is placed on the big toe of both feet of the patient.;Temperature sensation. Timepoint: Before the intervention and 1 and 2 months after the intervention. Method of measurement: Placing a cold fork on the patient's cheek and comparing the perception of the same cold temperature on the big toe of both feet.;Pin-prick sensation. Timepoint: Before the intervention and 1 and 2 months after the intervention. Method of measurement: Assess whether the patient can differentiate between the sharp and neutral ends of the appropriate pin on the dorsum of the toe and whether they can anatomically grasp a cotton swab in the same location.;Ankle reflex. Timepoint: Before the intervention and 1 and 2 months after the intervention. Method of measurement: Impacting below the knee in a sitting position by reflex hammer and evaluating reflex and response of quadriceps muscle.;NDS score (Neuropathy Disability Score). Timepoint: Before the intervention and 1 and 2 months after the intervention. Method of measurement: Collecting the patient's points in vibration, pin-prick, temperature, and ankle reflex tests for both lower limbs, which can be a number between 0 and 10. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArezoo Ranjbar Arani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed