Overweight and obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group 1: consume 120 cc of yogurt containing 10^10 TFU Ackermansia muciniphila postbiotic befor meal daily for 8 weeks. Intervention 2: Intervention group 2: consume 120 c
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Aged 20 - 50 years and not being menopause for females Being overweight or obese (Body mass index higher than 25) Not allergic to milk protein and Not lactose intolerant,not being gluten-intolerant Not suffering from known endocrine-related obesity, Inflammatory bowel disease, Irritable bowel syndrome, nouropathy, gastroparesis and gastrointestinal disorders at the beginning of the study Not suffering from thyroid diseases, diabetes, kidney disease, rheumatic diseases and migraine headache at the baseline did not use antibiotics for 2 months before the beginning of the study didn't take probiotic, prebiotic, and omega 3 supplements for 1month before the study Not taking part in other studies for 6 months before the study No weight reduction over 6 Kg in the last 3 months prior to the study no history of hospitalization or any surgery and bariateric surgery for 3 months before the study and 6 months after entering the study Not following special diets such as vegetarian or gluten free or weight-reducing diets Not infected with Covid-19 or any other infections or any hospitalization for 1 month before the study
Exclusion criteria
Exclusion criteria: planning for pregnancy for 6 months after the study and not having breast-feeding heavy alcohol use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Waist circumference. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: stadiometer.;Body weight. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: scale.;Body mass index. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: By calculating using the formula with using height and weight. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent of body fat. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: Body composition analyzer.;Lipopolysaccharide (LPS). Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: Enzyme-linked immuno_sorbent assay (ELISA) kit.;High-sensitivity C-reactive Protein (hs-CRP) blood level. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: Enzyme-linked immuno_sorbent assay (ELISA) kit.;Visceral body fat. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: Body composition analyzer.;Lean body mass. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: Body composition analyzer.;Waist to hip ratio. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: flexible meter.;Malondialdehyde (MDA). Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: spectrophotometry.;Appetite score. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: VAS questionnaire.;Depression score. Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: beck questionnaire.;Total antioxidant capacity (TAC). Timepoint: At the beginning of the study (before the intervention) and the end of the study (8 weeks after the intervention). Method of measurement: colorime | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactErfaneh Aalipanah
Shiraz University of Medical Sciences
Outcome results
None listed