Clinical Outcomes of two methods: platelet-rich plasma (PRP) in the Follicular Phase and simultaneously with Oocyte puncture after Ovarian Stimulation

Comparison of Clinical Outcomes of two methods: platelet-rich plasma (PRP) in the Follicular Phase and simultaneously with Oocyte puncture after Ovarian Stimulation: A Clinical Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230522058253N9

Enrollment

100

Registered

2025-12-26

Start date

2026-01-21

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Women diagnosed with poor ovarian response according to the Bologna criteria. Other ovarian dysfunction

Interventions

Intervention 1: Intervention group: Group A PRP injection in the follicular phase: The method is as follows: 20 ml of venous blood is prepared from each patient and after two-stage centrifugation and

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age 20-45 years At least one previous ovarian stimulation cycle with 3 or fewer oocytes retrieved Abnormal ovarian reserve test (poor ovarian) AFC <5 or AMH <1.2 ng/mL (Poseidon criteria 3, 4) Normal sperm analysis BMI <30 kg/m2 No fertility problems in the patient's husband

Exclusion criteria

Exclusion criteria: Pregnancy Ovarian failure due to gonadal dysgenesis and chromosomal abnormalities Uterine disorders Use of anticoagulants or psychotropic drugs Hemoglobin level less than 11 g/dl Platelets less than 150,000/mm3 Systemic use of corticosteroids in the two weeks before the intervention Psychiatric disorders Cancer Allergic reactions

Design outcomes

Primary

Measure	Time frame
Number of mature eggs (MII) after two PRP methods in the follicular phase and PRP simultaneously with puncture after ovarian stimulation. Timepoint: Primary outcomes include the number of mature oocytes (MII) obtained from puncture before and 2 months after the intervention. Method of measurement: All patients are monitored by ultrasound after PRP treatment and the number of mature eggs (MII) is determined.;AMH levels after two PRP procedures in the follicular phase and PRP simultaneously with puncture after ovarian stimulation. Timepoint: AMH levels are measured before and 2 months after the intervention. Method of measurement: AMH levels are assessed by taking blood from the patient before and one and two months after the intervention.	—

Measure

Time frame

Number of mature eggs (MII) after two PRP methods in the follicular phase and PRP simultaneously with puncture after ovarian stimulation. Timepoint: Primary outcomes include the number of mature oocytes (MII) obtained from puncture before and 2 months after the intervention. Method of measurement: All patients are monitored by ultrasound after PRP treatment and the number of mature eggs (MII) is determined.;AMH levels after two PRP procedures in the follicular phase and PRP simultaneously with puncture after ovarian stimulation. Timepoint: AMH levels are measured before and 2 months after the intervention. Method of measurement: AMH levels are assessed by taking blood from the patient before and one and two months after the intervention.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactshahedeh khansari

Hamedan University of Medical Sciences

dr_sh_kh@yahoo.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026